Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system
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چکیده
منابع مشابه
Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system.
Mismatch repair (MMR)-deficient cells are shown to produce >15-fold more methotrexate-resistant colonies than MMR normal cells. The increased resistance to methotrexate is primarily due to gene amplification since all the resistant clones contain double-minute chromosomes and increased copy numbers of the DHFR gene. In addition, integration of linearized or retroviral DNAs into chromosomes is a...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2001
ISSN: 1362-4962
DOI: 10.1093/nar/29.16.3304